Selected Publications

Price, K.L., Lamb H., Alvarado, J.C., and Rose, L.S. The DEPDC1 protein LET-99 is required for cortical stability and antagonizes branched actin formation to promote robust cytokinesis In revision, preprint available at bioRxiv 2022.09.07.506988; doi:

Koch L.A. , Rose L.S. (2023) Multiple pathways for reestablishing PAR polarity in C. elegans embryos. Dev Biol. 500:40-54. doi: 10.1016/j.ydbio.2023.05.005. Online ahead of print. PMID: 37263374

Liro, M.J., Morton, D.G. and Rose, L.S. (2018) The kinases PIG-1 and PAR-1 act in redundant pathways to regulate asymmetric division in the EMS blastomere of C. elegans. Dev Biol. 444(1):9-19.

Price, K.L. and Rose, L.S. (2017) LET-99 functions in the astral furrowing pathway where it is required for myosin enrichment in the contractile ring. Mol Biol Cell  pii: mbc.E16-12-0874.

Liro, M.J. and Rose, L.S. (2016) Mitotic Spindle Positioning in the EMS Cell of Caenorhabditis elegans Requires LET-99 and LIN-5/NuMA. Genetics 204(3):1177-1189.

Wu, J.C., Espiritu. E.B., Rose, L.S. (2016) The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein. Dev Biol. 412(2):288-297.

VanGompel Michael J.W., Nguyen Ken C.Q., Hall David H., DauerWilliam T., and Rose Lesilee S. 2015. A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. MBoC.

Espiritu Eugenel B., and Rose Lesilee S. 2013. Caenorhabditis elegans Embryo: Establishment of Asymmetry. eLS.

Espiritu Eugenel B., Krueger Lori E., Ye A, and Rose Lesilee S. 2012. CLASPs function redundantly to regulate astral microtubules in the C. elegans embryo. Dev Bio. 368(2), 242-54.

Hwang Sue Y., Rose Lesilee S. 2010. Control of asymmetric cell division in early C. elegans embryogenesis: teaming-up translational repression and protein degradation. BMB Rep. 243, 69-78.

Krueger, Lori E., Jui-Ching Wu, Meng-Fu Bryan Tsou and Lesilee S. Rose. Lateral inhibition of cortical pulling forces by LET-99 regulates asymmetric spindle positioning in C. elegans embryos. J Cell Bio 189, 481-95.

Wei Li, Leah DeBella, Tugba Guven-Ozkan, Rueyling Lin and Lesilee Rose. 2009. An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos. J Cell Bio 187, 33-42.

Zhu, Li, James O. Wrabl, Adam P. Hayashi, Lesilee S. Rose and Philip J. Thomas. 2008. The Torsin-family AAA Protein OOC-5 Contains a Critical Disulfide Adjacent to Sensor-II That Couples Redox State to Nucleotide Binding. Mol. Biol. Cell 19:3599-3612.

Park, Dae Hwi and Lesilee S. Rose. 2008. Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning. Dev Biol 315, 42-54.

Wu, Jui-Ching, and Lesilee S. Rose. 2007. PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in C. elegans embryos. Mol Biol Cell. 18:4470-82.

DeBella, Leah R., Adam Hayashi, and Lesilee S. Rose. 2006. LET-711, the C. elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos. Mol. Biol. Cell 17:4911-4924.

Gönczy, Pierre, and Lesilee S. Rose. 2005. Asymmetric cell division and axis formation in the embryo. In WormBook, ed.The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.7.1,

Bergmann, Dominique C., Monica Lee, Barbara Robertson, Meng-Fu Bryan Tsou, Lesilee S. Rose and William B. Wood. 2003. Embryonic handedness choice in C. elegans involves a G-alpha protein encoded by the gpa-16 gene. Development 130(23): 5731-40.

Tsou, Meng-Fu Bryan, Adam Hayashi, and Lesilee S. Rose. 2003. LET-99 opposes G/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling. Development 130(23), 5717-30.

Tsou , Meng-Fu Bryan, Wei Ku, Adam Hayashi, and Lesilee S. Rose. 2003. PAR-dependent and geometry-dependent mechanisms of spindle positioning. J Cell Bio1: 160(6):845-55.

Tsou, Meng-Fu, Adam Hayashi, Leah R. DeBella, Garth McGrath, and Lesilee S. Rose. 2002.  LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos. Development, 129: 4469-4481.

Basham, Stephen E. and Lesilee S. Rose. 2001. The Caenorhabditis elegans polarity gene ooc-5 encodes a Torsin-related protein of the AAA ATPase superfamily. Development 128(22):4645-4656.

Basham, Stephen E. and Lesilee S. Rose. 1999. Mutations in ooc-5 and ooc-3 disrupt oocyte formation and the reestablishment of asymmetric PAR protein localization in 2-cell C. elegans embryos. Developmental Biology 215: 253-263.